Information collapse in periodontitis: Toll-like receptors and immune signaling hijacking
Periodontitis is more than microbial overgrowth in the oral cavity; it represents a sophisticated subversion of the host immune system. At the center of this process is the collapse of Toll-Like Receptor (TLR)–mediated signaling, whereby the host’s defense mechanisms are co-opted to sustain a chronic, dysbiotic state rather than eliminate pathogens.