Antiresorptive Medication Effects on Dental Implant Survival and Implant-Related Jaw Osteonecrosis

Antiresorptive therapy: 1) decreased osteoclastogenesis leads to osteoclast apoptosis and decreased bone resorption; 2) decreased osteoblastogenesis leads to decreased bone formation.19

Dental implants to replace missing teeth are a predictable treatment option with survival rates ranging as high as 98 to 99%.1-6 Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) is a serious dental surgical post-operative risk for patients on antiresorptive medications, and may also interfere with dental implant osteointegration. The data on antiresorptive medication-associated implant failure … Read more